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Covariates
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Quartile 1
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Quartile 2
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Quartile 3
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Quartile 4
|
P
|
|---|
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Sample size
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41
|
41
|
41
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41
|
|---|
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Nrg4 (ng/ml)
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1.18 ± 0.31
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2.14 ± 0.31**
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3.26 ± 0.33**##
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5.18 ± 1.08**##$$
|
0.000
|
|
Men/women
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24/17
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20/21
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15/26
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19/22
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0.263
|
|
Age (years)
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65.46 ± 9.70
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61.29 ± 7.96*
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62.37 ± 8.92
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66.44 ± 9.19$
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0.030
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BMI (kg/m2)
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26.55 ± 3.69
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25.79 ± 3.95*
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25.02 ± 3.90
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24.72 ± 3.39*
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0.119
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SBP (mmHg)
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123.51 ± 11.16
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122.56 ± 11.50
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124.83 ± 13.19
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127.00 ± 10.98
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0.351
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DBP (mmHg)
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72.07 ± 11.29
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73.37 ± 9.32
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75.73 ± 8.18
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74.24 ± 7.05
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0.333
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FBG (mmol/L)
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11.48 ± 3.73
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11.79 ± 3.69
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10.38 ± 2.83
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10.44 ± 3.18
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0.140
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PBG (mmol/L)
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18.82 ± 4.76
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19.19 ± 5.92
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18.91 ± 7.62
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18.82 ± 5.26
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0.774
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HbA1c (mmol/mol)
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84.98 ± 23.16
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87.45 ± 20.99
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85.63 ± 25.90
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86.93 ± 27.21
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0.966
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HbA1c (%)
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9.93 ± 2.12
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10.15 ± 1.92
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9.99 ± 2.37
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10.10 ± 2.49
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0.966
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FIns (μU/ml)
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10.05 ± 6.35
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11.71 ± 6.29
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10.26 ± 5.32
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10.68 ± 6.56
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0.624
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HOMA-IR
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4.76 ± 2.96
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6.12 ± 3.85
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4.65 ± 2.75
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4.84 ± 3.44
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0.145
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TC (mmol/L)
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4.42 ± 1.23
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4.37 ± 1.33
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4.36 ± 1.18
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4.56 ± 1.40
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0.893
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TG (mmol/L)
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2.30 ± 2.69
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2.32 ± 1.53
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1.55 ± 0.80
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2.42 ± 2.21*
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0.082
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HDL-C (mmol/L)
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1.07 ± 0.31
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1.10 ± 0.46
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1.16 ± 0.32*
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1.16 ± 0.36**
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0.543
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LDL-C (mmol/L)
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2.67 ± 0.91
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2.51 ± 0.92
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2.74 ± 1.03
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2.70 ± 1.08
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0.731
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UACR (mg/g)
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39.46 ± 8.70
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38.02 ± 6.49
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38.07 ± 7.79
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52.84 ± 9.54
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0.123
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Scr (μmol/L)
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70.56 ± 21.03
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69.83 ± 18.44
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65.60 ± 16.44
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72.42 ± 19.46
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0.417
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eGFR (mL/min/1.73 m2)
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88.76 ± 22.44
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89.84 ± 15.55
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90.76 ± 16.95
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83.89 ± 16.29
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0.319
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|
ABI
|
1.04 ± 0.07
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1.05 ± 0.11
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1.02 ± 0.15
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1.01 ± 0.18
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0.880
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VPT (V)
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27.15 ± 11.37
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18.80 ± 10.06**
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14.29 ± 5.77**
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15.00 ± 6.78**
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0.000
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25(OH)D (ng/mL)
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15.91 ± 5.35
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14.11 ± 3.05**
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15.76 ± 4.51
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18.37 ± 6.15##
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0.007
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DPN, n (%)
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28 (68.29)
|
19 (46.34)
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16 (39.02)*
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13 (31.71)**
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0.006
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|
VPT > 25 V, n(%)
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28 (68.29)
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10 (24.39) **
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3 (7.32**##
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2 (4.88**##$$
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0.000
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Abnormal pricking sensation, n (%)
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34 (82.93)
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22 (53.66)
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25 (60.98)
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22 (53.66)
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0.250
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Abnormal nylon monofilament, n (%)
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8 (19.51)
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12 (29.27)
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11 (26.83)
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11 (26.83)
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0.808
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Reflex abnormalities, n (%)
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6 (14.63)
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5 (12.20)
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3 (7.32)
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2 (4.88)
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0.431
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Two abnormal DPN screening, n (%)
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20 (48.78)
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16 (39.02)
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15 (36.59)
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12 (29.27)
|
0.340
|
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Three or more abnormal DPN screening, n (%)
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8 (19.51)
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3 (7.32)
|
1 (2.44)**
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1 (2.44)**
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0.012
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DN, n (%)
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16 (39.02)
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18 (43.90)
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13 (31.71)
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19 (46.34)
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0.549
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DR, n (%)
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4 (9.76)
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6 (14.63)
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4 (9.76)
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6 (14.63)
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0.824
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PAD, n (%)
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3 (7.32)
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1 (2.44)
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4 (9.76)
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4 (9.76)
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0.543
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- *P < 0.05, **P < 0.01 compared with quartile 1 group; # < 0.05, ##0.01 compared with quartile 2 group; $ < 0.05, $$0.01 compared with quartile 3 group
