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Test characteristics (%)
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|---|
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Diagnostic test at 4–12 weeks PP
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Sensitivity (%)
|
Specificity (%)
|
PPV
(%)
|
NPV (%)
|
|---|
|
Prediction of glucose intolerance 1-year postpartum (n = 324)
|
|
Glucose tolerance defined by FPG and HbA1ca
|
|
Fasting glucose (mmol/l)
|
22.3
|
96.4
|
80.6
|
64.9
|
|
HbA1c (%)
|
21.5
|
87.5
|
53.8
|
62.2
|
|
2 hr glucose (mmol/l)
|
10.1
|
96.9
|
68.4
|
61.6
|
|
Fasting glucose and HbA1c
|
35.4
|
85.6
|
62.2
|
66.4
|
|
oGTT
|
26.9
|
93.8
|
74.5
|
65.7
|
|
oGTT and HbA1c
|
37.7
|
83.1
|
59.8
|
66.7
|
| |
Test characteristics (%)
|
|---|
|
Diagnostic test at 4–12 weeks PP
|
Sensitivity (%)
|
Specificity (%)
|
PPV (%)
|
NPV (%)
|
|---|
|
Prediction of glucose intolerance at 3-year postpartum (n = 69)
|
|
Glucose tolerance defined by FPG and HbA1ca
|
|
Fasting glucose (mmol/l)
|
22.2
|
95.2
|
75.0
|
65.6
|
|
HbA1c (%)
|
18.5
|
78.6
|
35.7
|
60.0
|
|
2 hr glucose (mmol/l)
|
5.8
|
95.1
|
54.0
|
59.1
|
|
Fasting glucose and HbA1c
|
37.0
|
76.2
|
50.0
|
65.3
|
|
oGTT
|
22.2
|
92.9
|
66.7
|
65.0
|
|
oGTT and HbA1c
|
37.0
|
73.8
|
47.6
|
64.6
|
| |
Test characteristics (%)
|
|---|
|
Diagnostic test at 1-year PP
|
Sensitivity (%)
|
Specificity (%)
|
PPV (%)
|
NPV (%)
|
|---|
|
Prediction of glucose intolerance at 3-year postpartum (n = 69)
|
|
Glucose tolerance defined by FPG and HbA1ca
|
|
Fasting glucose (mmol/l)
|
59.3
|
80.5
|
66.7
|
75.0
|
|
HbA1c (%)
|
29.6
|
90.5
|
66.7
|
66.7
|
|
Fasting glucose and HbA1c
|
77.8
|
76.2
|
67.7
|
84.2
|
- PPV positive predictive value, NPV negative predictive value, PP postpartum, FPG fasting glucose, oGTT oral glucose tolerance test and HbA1c glycated hemoglobin
- aFPG and HbA1c was considered as the gold standard of pathological glucose tolerance at 1-year or 3-year postpartum. Normal glucose tolerance defined as FPG < 5.6 mmol/l or HbA1c < 5.7%; Pathological glucose intolerance defined as FPG ≥ 5.6 mmol/l or HbA1c ≥ 5.7%
- Pathological glucose intolerance includes few women with diabetes and this concerns 10 women at 1-year and 1 woman at 3-year postpartum. Due to the low number of women who had diabetes, we grouped them into pathological glucose intolerance and therefore did not use the term prediabetes
