Articles

Appropriate waist circumference cut points for identifying insulin resistance in black youth: a cross sectional analysis of the 1986 Jamaica birth cohort

While the International Diabetes Federation (IDF) has ethnic specific waist circumference (WC) cut-points for the metabolic syndrome for Asian populations it is not known whether the cut-points for black popul...

Authors: Marshall K Tulloch-Reid, Trevor S Ferguson, Novie OM Younger, Jan Van den Broeck, Michael S Boyne, Jennifer M Knight-Madden, Maureen E Samms-Vaughan, Deana E Ashley and Rainford J Wilks

Prevalence of Metabolic Syndrome and its influence on microvascular complications in the Indian population with Type 2 Diabetes Mellitus. Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetic Study (SN-DREAMS, report 14)

The Metabolic syndrome (MS) consists of central obesity, glucose intolerance, hyperinsulinemia, low high density lipoproteins, high triglycerides and hypertension. Different studies have observed that MS cause...

Authors: Rajiv Raman, Aditi Gupta, Swakshyar S Pal, Suganeswari Ganesan, Kadri Venkatesh, Vaitheeswaran Kulothungan and Tarun Sharma

Oral Insulin

Oral insulin is an exciting area of research and development in the field of diabetology. This brief review covers the various approaches used in the development of oral insulin, and highlights some of the rec...

Authors: Sanjay Kalra, Bharti Kalra and Navneet Agrawal

Metabolic syndrome is linked to a mild elevation in liver aminotransferases in diabetic patients with undetectable non-alcoholic fatty liver disease by ultrasound

Despite ongoing findings on the relationship between elevated levels of alanine and aspartate aminotransferases (ALT and AST) and metabolic syndrome (MetS), this association in diabetic patients without a know...

Authors: Alireza Esteghamati, Arsia Jamali, Omid Khalilzadeh, Sina Noshad, Mohammad Khalili, Ali Zandieh, Afsaneh Morteza and Manouchehr Nakhjavani

Insulin effect on glucose transport in thymocytes and splenocytes from rats with metabolic syndrome

Metabolic syndrome (MS) may comprise several clinical conditions such as obesity, diabetes and inflammatory disorders, which are characterized by metabolic imbalances. The study of glucose transport and regula...

Authors: Roxana Carbó and Verónica Guarner

Prevalence of diabetes mellitus and impaired glucose tolerance in a rural community of Angola

To determine the prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) in a rural community (Bengo) of Angola.

Authors: Antonio D Evaristo-Neto, Maria Cristina Foss-Freitas and Milton C Foss

Conjugated Linoleic Acid: good or bad nutrient

Conjugated linoleic acid (CLA) is a class of 28 positional and geometric isomers of linoleic acid octadecadienoic.Currently, it has been described many benefits related to the supplementation of CLA in animals...

Authors: Daniela C Gonçalves, Fabio S Lira, Luiz C Carnevali Jr, Jose C Rosa, Gustavo D Pimentel and Marília Seelaender

Gum Guar fiber associated with fructose reduces serum triacylglycerol but did not improve the glucose tolerance in rats

The increased intake of dietary fructose can be associated with alterations on energy homeostasis and lipid/carbohydrate metabolism, such as insulin resistance and dislipidemia. On the other hand, the ingestio...

Authors: Caio SM Motoyama, Mônica JS Pinto, Fabio S Lira, Eliane B Ribeiro, Claudia MO do Nascimento and Lila M Oyama

Sudeck's disease stage 1, or diabetic Charcot's foot stage 0? Case report and assessment of the diagnostic value of MRI

The diagnosis of Sudeck's syndrome stage 1 (nowadays termed complex regional pain syndrome I, abbreviated CRPS I) is based on clinical features, namely swelling and pain in a limb. Plain X-ray may be normal. I...

Authors: Ludger W Poll, Philipp Weber, Hermann-Josef Böhm, Nahid Ghassem-Zadeh and Ernst A Chantelau

Metabolic syndrome in menopausal transition: Isfahan Healthy Heart Program, a population based study

There is a remarkable increase in cardiovascular disease after menopause. On the other hand, metabolic syndrome as a collection of risk factors has a known effect on cardiovascular diseases. Hormone changes ar...

Authors: Ramin Heidari, Masoumeh Sadeghi, Mohammad Talaei, Katayoun Rabiei, Noushin Mohammadifard and Nizal Sarrafzadegan

Dietary iron intake in the first 4 months of infancy and the development of type 1 diabetes: a pilot study

To investigate the impact of iron intake on the development of type 1 diabetes (T1DM).

Authors: Ambika P Ashraf, Nancy B Eason, Edmond K Kabagambe, Josna Haritha, Sreelatha Meleth and Kenneth L McCormick

Erratum to: Assessment of efficacy and tolerability of once-daily extended release metformin in patients with type 2 diabetes mellitus

Authors: Juliana Levy, Roberta A Cobas and Marília B Gomes

Symptomatic cerebral oedema during treatment of diabetic ketoacidosis: effect of adjuvant octreotide infusion

A potentially lethal complication of diabetic ketoacidosis (DKA) in children is brain oedema, whether caused by DKA itself or by the therapeutic infusion of insulin and fluids.

Authors: Ora Seewi, Anne Vierzig, Bernhard Roth and Eckhard Schönau

Metabolic syndrome, dyslipidemia, hypertension and type 2 diabetes in youth: from diagnosis to treatment

Overweight and obesity in youth is a worldwide public health problem. Overweight and obesity in childhood and adolescents have a substantial effect upon many systems, resulting in clinical conditions such as m...

Authors: Alfredo Halpern, Marcio C Mancini, Maria Eliane C Magalhães, Mauro Fisberg, Rosana Radominski, Marcelo C Bertolami, Adriana Bertolami, Maria Edna de Melo, Maria Teresa Zanella, Marcia S Queiroz and Marcia Nery

Effect of the carbohydrate counting method on glycemic control in patients with type 1 diabetes

The importance of achieving and maintaining an appropriate metabolic control in patients with type 1 diabetes mellitus (DM1) has been established in many studies aiming to prevent the development of chronic co...

Authors: Viviane M Dias, Juliana A Pandini, Raquel R Nunes, Sandro LM Sperandei, Emilson S Portella, Roberta A Cobas and Marília de B Gomes

Body weight, metabolism and clock genes

Biological rhythms are present in the lives of almost all organisms ranging from plants to more evolved creatures. These oscillations allow the anticipation of many physiological and behavioral mechanisms thus...

Authors: Melissa M Zanquetta, Maria Lúcia Corrêa-Giannella, Maria Beatriz Monteiro and Sandra MF Villares

Predictive factors of non-deterioration of glucose tolerance following a 2-year behavioral intervention

To identify predictive factors associated with non-deterioration of glucose metabolism following a 2-year behavioral intervention in Japanese-Brazilians.

Authors: Bianca Almeida-Pititto, Amélia T Hirai, Daniela S Sartorelli, Helena A Harima, Suely GA Gimeno and Sandra RG Ferreira

Lipoprotein (a), C-reactive protein and some metabolic cardiovascular risk factors in type 2 DM

Lipoprotein (a) (LP (a) is an independent cardiovascular risk factor that is not widely studied in people of sub-Saharan African origin. The aim of this report is to determine the frequency of occurrence of el...

Authors: Anthonia O Ogbera and Alfred O Azenabor

Serum aspirin esterase is strongly associated with glucose and lipids in healthy subjects: different association patterns in subjects with type 2 diabetes mellitus

Aspirin esterase (AE) activity can account for part of aspirin pharmacokinetics in the circulation, possibly being associated with the impairment of aspirin effectiveness as an inhibitor of platelet aggregation.

Authors: Kazuhiko Kotani, Satoshi Kimura, Tetsu Ebara, Russell Caccavello and Alejandro Gugliucci

Impact of hyperglycemia on morbidity and mortality, length of hospitalization and rates of re-hospitalization in a general hospital setting in Brazil

Hyperglycemia in hospitalized patients is known to be related to a higher incidence of clinical and surgical complications and poorer outcomes. Adequate glycemic control and earlier diagnosis of type 2 diabete...

Authors: Silmara AO Leite, Simone B Locatelli, Sabrina P Niece, Aline RF Oliveira, Deborah Tockus and Thaísa Tosin

Diabetes-related molecular signatures in infrared spectra of human saliva

There is an ongoing need for improvements in non-invasive, point-of-care tools for the diagnosis and prognosis of diabetes mellitus. Ideally, such technologies would allow for community screening.

Authors: David A Scott, Diane E Renaud, Sathya Krishnasamy, Pinar Meriç, Nurcan Buduneli, Şvetki Çetinkalp and Kan-Zhi Liu

Is exercise a therapeutic tool for improvement of cardiovascular risk factors in adolescents with type 1 diabetes mellitus? A randomised controlled trial

Type 1 diabetes mellitus (T1DM) is associated with a high risk for early atherosclerotic complications especially risk of coronary heart disease.

Authors: Mona A Salem, Mohammed A AboElAsrar, Nancy S Elbarbary, Rana A ElHilaly and Yara M Refaat

Effect of taurine supplementation on hyperhomocysteinemia and markers of oxidative stress in high fructose diet induced insulin resistance

High intake of dietary fructose is accused of being responsible for the development of the insulin resistance (IR) syndrome. Concern has arisen because of the realization that fructose, at elevated concentrati...

Authors: Hala O El Mesallamy, Ebtehal El-Demerdash, Lamiaa N Hammad and Hekmat M El Magdoub

The effectiveness of educational practice in diabetic foot: a view from Brazil

The aim of the present study was to evaluate the prevention and self-inspection behavior of diabetic subjects with foot at ulcer risk, no previous episode, who participated in the routine visits and standardiz...

Authors: Maria I Anselmo, Marcia Nery and Maria CR Parisi

Combination therapy in hypertension: An update

Meticulous control of blood pressure is required in patients with hypertension to produce the maximum reduction in clinical cardiovascular end points, especially in patients with comorbidities like diabetes me...

Authors: Sanjay Kalra, Bharti Kalra and Navneet Agrawal

Chronic consumption of fructose rich soft drinks alters tissue lipids of rats

Fructose-based diets are apparently related to the occurrence of several metabolic dysfunctions, but the effects of the consumption of high amounts of fructose on body tissues have not been well described. The...

Authors: Jose D Botezelli, Rodrigo A Dalia, Ivan M Reis, Ricardo A Barbieri, Tiago M Rezende, Jailton G Pelarigo, Jamile Codogno, Raquel Gonçalves and Maria A Mello

Influence of muscle fitness test performance on metabolic risk factors among adolescent girls

The purpose of this study was to examine the association between muscular fitness (MF), assessed by 2 components of Fitnessgram test battery, the Curl-Up and Push-Ups tests and the metabolic risk score among a...

Authors: Jorge Mota, Susana Vale, Clarice Martins, Anelise Gaya, Carla Moreira, Rute Santos and José C Ribeiro

Alternative management of diabetic ketoacidosis in a Brazilian pediatric emergency department

DKA is a severe metabolic derangement characterized by dehydration, loss of electrolytes, hyperglycemia, hyperketonemia, acidosis and progressive loss of consciousness that results from severe insulin deficien...

Authors: Roberta D Savoldelli, Sylvia CL Farhat and Thais D Manna

Obesity and metabolic syndrome in 7-9 years-old Portuguese schoolchildren

Body fat is related to changes in lipid profile, blood pressure and metabolism of insulin and glucose, known as the metabolic syndrome (MS). The aim of this study was to estimate the prevalence of metabolic sy...

Authors: Carla Pedrosa, Bruno MPM Oliveira, Isabel Albuquerque, Carlos Simões-Pereira, Maria D Vaz-de-Almeida and Flora Correia

Metabolic syndrome in overweight children from the city of Botucatu - São Paulo State - Brazil: agreement among six diagnostic criteria

The metabolic syndrome has been described in children; however, a standard criterion has not been established for its diagnosis. Also, few studies have been conducted to specifically observe the possible exist...

Authors: Ana Elisa M Rinaldi, Gustavo D Pimentel, Avany F Pereira, Gleice FCP Gabriel, Fernando Moreto and Roberto C Burini

Disassociated relation between plasma tumor necrosis factor-α, interleukin-6 and increased body weight in Amerindian women: A long-term prospective study of natural body weight variation and impaired glucose tolerance

Inflammatory cytokines are linked to obesity-related insulin resistance and may predict type 2 diabetes independently of obesity. We previously reported that a majority of a cohort of 73 non-diabetic women wit...

Authors: Folke Lindgärde, Anders Gottsäter and Bo Ahrén

Evaluation of neonatally-induced mild diabetes in rats: Maternal and fetal repercussions

Many experimental studies have been performed to evaluate mild diabetes effects. However, results are divergent regarding glycemia and insulin measurement, fetal macrossomia, and placental weights. The aim was...

Authors: Isabela L Iessi, Aline Bueno, Yuri K Sinzato, Kristin N Taylor, Marilza VC Rudge and Débora C Damasceno

Clustering of metabolic syndrome components in a Middle Eastern diabetic and non-diabetic population

Metabolic syndrome (MetS) encompasses a cluster of coronary heart disease and diabetes mellitus risk factors. In this study, we aimed to elucidate the factors underlying the clustering of MetS components in di...

Authors: Alireza Esteghamati, Ali Zandieh, Omid Khalilzadeh, Alipasha Meysamie and Haleh Ashraf

Algorithm for the treatment of type 2 diabetes: a position statement of Brazilian Diabetes Society

The Brazilian Diabetes Society is starting an innovative project of quantitative assessment of medical arguments of and implementing a new way of elaborating SBD Position Statements. The final aim of this part...

Authors: Antonio C Lerario, Antonio R Chacra, Augusto Pimazoni-Netto, Domingos Malerbi, Jorge L Gross, José EP Oliveira, Marilia B Gomes, Raul D Santos, Reine MC Fonseca, Roberto Betti and Roberto Raduan

Synergistic effect of simvastatin and ezetimibe on lipid and pro-inflammatory profiles in pre-diabetic subjects

Ezetimibe specifically blocks the absorption of dietary and biliary cholesterol and plant sterols. Synergism of ezetimibe-statin therapy on LDL-cholesterol has been demonstrated, but data concerning the pleiot...

Authors: Ana-Lucia A Kater, Marcelo C Batista and Sandra RG Ferreira

Three-dimensional structure of β-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W

We examined the effects of the R325W mutation on the three-dimensional (3D) structure of the β-cell-specific Zn²⁺ (zinc) transporter ZnT-8.

Authors: Rob NM Weijers

Risk factors for myocardial infarction among low socioeconomic status South Indian population

As longevity increases, cases of myocardial infarction (MI) are likely to be more. Cardiovascular disease (CVD) is a major global health problem reaching epidemic proportions in the Indian subcontinent, also a...

Authors: Ramachandran Meenakshisundaram, Dipti Agarwal, Chinnaswamy Rajendiran and Ponniah Thirumalaikolundusubramanian

Low and moderate, rather than high intensity strength exercise induces benefit regarding plasma lipid profile

The effects of chronic aerobic exercise upon lipid profile has been previously demonstrated, but few studies showed this effect under resistance exercise conditions.

Authors: Fabio S Lira, Alex S Yamashita, Marco C Uchida, Nelo E Zanchi, Bruno Gualano, Eivor Martins Jr, Erico C Caperuto and Marília Seelaender

Association between insulin resistance and c-reactive protein among Peruvian adults

Insulin resistance (IR), a reduced physiological response of peripheral tissues to the action of insulin, is one of the major causes of type 2 diabetes. We sought to evaluate the relationship between serum C-r...

Authors: Bizu Gelaye, Luis Revilla, Tania Lopez, Luis Suarez, Sixto E Sanchez, Karin Hevner, Annette L Fitzpatrick and Michelle A Williams

Improvement of renal oxidative stress markers after ozone administration in diabetic nephropathy in rats

Several complications of diabetes mellitus (DM) e.g. nephropathy (DN) have been linked to oxidative stress. Ozone, by means of oxidative preconditioning, may exert its protective effects on DN.

Authors: Mohamed D Morsy, Waleed N Hassan and Sherif I Zalat

Comparison of body mass index and waist circumference as predictors of cardiometabolic health in a population of young Canadian adults

This study aimed to investigate whether waist circumference (WC) or body mass index (BMI) is a better predictor of blood lipid concentrations among young men and women from different ethnocultural groups.

Authors: Darren R Brenner, Kasia Tepylo, Karen M Eny, Leah E Cahill and Ahmed El-Sohemy

Dysglycemias in pregnancy: from diagnosis to treatment. Brazilian consensus statement

There is an urgent need to find consensus on screening, diagnosing and treating all degrees of DYSGLYCEMIA that may occur during pregnancies in Brazil, considering that many cases of DYSGLYCEMIA in pregnant wo...

Authors: Carlos Antonio Negrato, Renan M Montenegro Jr, Rosiane Mattar, Lenita Zajdenverg, Rossana PV Francisco, Belmiro Gonçalves Pereira, Mauro Sancovski, Maria Regina Torloni, Sergio A Dib, Celeste E Viggiano, Airton Golbert, Elaine CD Moisés, Maria Isabel Favaro, Iracema MP Calderon, Sonia Fusaro, Valeria DD Piliakas…

Repercussions of mild diabetes on pregnancy in Wistar rats and on the fetal development

Experimental models are necessary to elucidate diabetes pathophysiological mechanisms not yet understood in humans. Objective: To evaluate the repercussions of the mild diabetes, considering two methodologies,...

Authors: Felipe H Saito, Débora C Damasceno, Wilma G Kempinas, Glilciane Morceli, Yuri K Sinzato, Kristin N Taylor and Marilza VC Rudge

Routine MRI findings of the asymptomatic foot in diabetic patients with unilateral Charcot foot

Imaging studies of bones in patients with sensory deficits are scarce.

Authors: Ludger W Poll and Ernst A Chantelau

Hyperuricaemia and the metabolic syndrome in type 2 DM

Elevated serum uric acid levels (SUA) have been associated with an increased risk of cardiovascular diseases and the metabolic syndrome (MetS) and are often reported to be higher in females than in males. The ...

Authors: Anthonia O Ogbera and Alfred O Azenabor

Gradient-echo magnetic resonance imaging study of pancreatic iron overload in young Egyptian beta-thalassemia major patients and effect of splenectomy

Thalassemic patients suffer from diabetes mellitus secondary to hemosiderosis.

Authors: Randa M Matter, Khalid E Allam and Amany M Sadony

Association of cardiometabolic risk factors and dental caries in a population-based sample of youths

Cardiovascular disease (CVD) risk factors begin from early life and track onto adulthood. Oral and dental diseases share some risk factors with CVD, therefore by finding a clear relation between dental disease...

Authors: Roya Kelishadi, Shiva Mortazavi, Tavakol R Hossein and Parinaz Poursafa

Visfatin, glucose metabolism and vascular disease: a review of evidence

The adipose tissue is an endocrine organ producing substances called adipocytokines that have different effects on lipid metabolism, metabolic syndrome, and cardiovascular risk. Visfatin was recently described...

Authors: Pedro Saddi-Rosa, Carolina SV Oliveira, Fernando MA Giuffrida and André F Reis

Absence of diabetic retinopathy in a patient who has had diabetes mellitus for 69 years, and inadequate glycemic control: case presentation: response

A response to Jorge Esteves, Carolina Maurente da Rosa, Caroline Kaercher Kramer, Luiz Eduardo Osowski, Stéfano Milano and Luís Henrique Canani: Absence of diabetic retinopathy in a patient who has had diabete...

Authors: Rajiv Raman and Aditi Gupta

Metabolic Syndrome: a challenging health Issue in highly urbanized Union Territory of north India

1. To determine the prevalence of Metabolic Syndrome in adults aged 18 years and above in Chandigarh, India. 2. To determine the socio-demographic factors associated with MS. 3. To determine the agreement betw...

Authors: Chetna Mangat, NK Goel, Dinesh K Walia, Neeraj Agarwal, Munesh K Sharma, Jasbinder Kaur, Ram Singh and Gagandeep Singh